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What is Ozempic?
Both Ozempic and Wegovy are brand names of Semaglutide. This is a long-acting GLP-1 receptor agonist, which can be administered subcutaneously once a week.

It has been shown to be effective for weight loss in trials involving patients with or without type 2 diabetes. In fact, Ozempic was actually developed to treat type 2 diabetes as it helps lower blood glucose levels.

But it ended up having a secondary weight loss benefit which was then perpetuated as people without type 2 diabetes began requesting Ozempic to help lose weight.

Keep in mind that only the injectable form, Wegovy, is approved for the treatment of obesity (not the oral version).
Semglutide has also been shown to reduce cardiovascular (CV) risk factors in patients with established CV disorders in some CV outcome trials.
How does Ozempic work for weight loss?
Once you are considered overweight or obese, the treatment is as follows: Ozempic injections at the maximum dose (2.4 mg weekly) help to achieve maximum weight loss.
But patients should not start on the maximum dose right away, as some cannot tolerate the dose and may have side effects, such as nausea or vomiting. That is why a gradual increase in the dose is recommended.
How Semaglutide (Ozempic and Wegovy) works for weight loss is quite interesting. GLP-1 is a major incretin hormone in humans. That is, it increases the section of insulin, inhibits the release of glucagon, and suppresses hepatic gluconeogenesis.
Semaglutide also causes delayed gastric emptying, reduced appetite and energy intake, so it has beneficial effects for weight loss. It slows down the rate at which the stomach empties food after a meal (gastric emptying). The longer it takes for the stomach to empty, the longer the food stays in the stomach, making you feel full for longer.
This results in reduced hunger and appetite. In general, patients taking Ozempic or Wegovy end up eating less food and therefore lose weight.
Ozempic not only affects gastric emptying, but it also affects the GLP-1 receptors found in the hypothalamus that are responsible for regulating food intake in the nervous system. This reduces the feeling of hunger and appetite in obese people.

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In addition, GLP-1 also affects receptors responsible for satiety in the brain. It stimulates these specific neurons, which increases satiety in patients who were given Ozempic. Now that you know what Ozempic is used for, let's take a closer look at the dosage and other administration instructions.
Where do I inject Ozempic?
A study showed that taking Ozempic on an empty stomach has the most optimal effect in achieving therapeutic concentration. Fasting for another half hour after taking the dose is beneficial.
Also, Ozempic should be administered under the skin, in the subcutaneous or fatty layer, in the lower abdomen (near the waist), the front of the thighs, or the upper arm. Do not inject Ozempic into a muscle or vein.
Be sure to rotate (change) the injection site with each injection. Do not use the same injection site with each injection, or if you choose the same site, do not use the same site each time.
The dosage of Ozempic needs to be adjusted. That is, patients should start therapy with 0.25 mg, then increase it to 0.5 mg and then to 1 mg, maintaining an interval of 4 weeks. The Ozempic pen (red and blue) is available in a concentration of 1.34 mg/ml.
The red pen delivers a starting dose of 0.25 mg and 0.5 mg for maintenance purposes. On the other hand, the blue pen is designed for 1.0 mg (maximum maintenance dose) of semaglutide.
What foods should I avoid while taking Ozempic?
When patients start taking Ozempic, some side effects may appear such as diarrhea, nausea or vomiting. But these may disappear over time as the patient gets used to the medication.
To help the body adapt to the medication and the dose, it is recommended to avoid fried and greasy foods, such as fast food and foods high in sugar. Ozempic and greasy foods are not friends: they can exacerbate the side effects.

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