It would likely result in a sudden increase in hormone levels, but it wouldn't have a long-term impact. The levels would gradually return to normal over a few weeks, depending on the ester used.
For me, if my gyno issues flared up, it would be really difficult. It's hard to say what would happen for you, but you wouldn't get much benefit from a single large dose like that.
Testosterone should always be the focus until you reach the highest dose you can handle without experiencing estrogen-related side effects. Once you reach that limit and can't progress further with testosterone alone, the next safest compound to consider adding is Primobolan.